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吕 妍

发布日期:2020-03-27 16:10|浏览量:   来源:  

一、个人简介(含学习经历、工作经历、社会兼职)

吕妍,女,1990年2月生,工学博士,校聘教授。

2012年本科毕业于厦门大学化学威尼斯官网,获学士学位;2015年于浙江大学获硕士学位;2019年毕业于新加坡南洋理工大学获博士学位。2020年加入威尼斯官网任教。

二、研究领域

1、调控细胞活性及生物学行为,如离子通道开合、基因编辑与表达等,以探索细胞内代谢通路及信号传递过程,加深对皮肤修复、衰老等行为的机理认知。

2、代谢工程、微生物发酵,以生产可作为化妆品原料的生物活性物。

3、蛋白质工程,以应用于改造化妆品生物活性物生产过程中的关键酶,优化生产效率。

4、开发化妆品有效成分的有效递送体系。

5、开发生物传感器及分子探针,以应用于化妆品功效评估。

三、奖励与荣誉(含各类荣誉及科技获奖,可根据实际情况填写)

1、最佳论文(Best thesis),2019

2、毕业生海报演讲(SCBE Ph.D. symposium)银奖(二等奖),2018

3、国家优秀自费留学生奖学金,2017

四、学术成果

(一)代表性科研项目(限5项)

1、Development of Smart Photoacoustic Nanoprobes to Image Reactive Oxygen Species in Tumor for In Vivo Drug Screening, AcRF Tier 1, Singapore

2、Organic photonic nanoprobes for in vivo imaging of neurodegenerative diseases, AcRF Tier 2, Singapore

3、定向进化提高磷脂酶PLC的酶活(横向,益海嘉里合作项目)

(二)代表性论文(限10篇)

1、Yan Lyu, Shasha He, Jingchao Li, Yuyan Jiang, He Sun, Yansong Miao, Kanyi Pu*. Photolabile Semiconducting Polymer Nanotransducer for Near-infrared Regulation of CRISPR/Cas9 Gene Editing.Angewandte Chemie International Edition,2019,58, 18197.

2、Yan Lyu, Dong Cui, Jiaguo Huang, Wenxuan Fan, Yansong Miao, Kanyi Pu*.Near‐Infrared Afterglow Semiconducting Nano‐polycomplexes for Multiplex Differentiation of Cancer Exosomes.Angewandte Chemie International Edition (VIP),2019,58, 4983.

3、Jiaguo Huang, Jingchao Li,Yan Lyu, Qingqing Miao, Kanyi Pu.Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury.Nature Materials,2019,18, 1133.

4、Yan Lyu,Jingqi Tian, Jingchao Li, Peng Chen, Kanyi Pu*.Semiconducting polymer nanobiocatalysts for photoactivation of intracellular redox.Angewandte Chemie International Edition,2018, 57, 13484

5、Yan Lyu, Jianfeng Zeng, Yuyan Jiang, Xu Zhen, Shanshan Qiu, Ting Wang, Xin Lou, Mingyuan Gao, Kanyi Pu*.Enhancing both biodegradability and efficacy of semiconducting polymer nanoparticles for photoacoustic imaging and photothermal therapy.ACS Nano,2018,12, 1801.

6、Yan Lyu, Dong Cui, He Sun, Yansong Miao, Hongwei Duan, Kanyi Pu*.Dendronized semiconducting polymer as photothermal nanocarrier for remote activation of gene expression.Angewandte Chemie International Edition,2017,129, 9283.

7、Yan Lyu, Xu Zhen, Yansong Miao, Kanyi Pu*. Reaction-based semiconducting polymer nanoprobes for photoacoustic imaging of protein sulfenic acids.ACS Nano,2017,11, 358.

8、Qingqing Miao, Chen Xie, Xu Zhen,Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V. Jokerst, Kanyi Pu*.Molecular afterglow imaging with bright, biodegradable polymer nanoparticles.Nature Biotechnology,2017,35, 1102.

9、Yan Lyu, Chen Xie, Svetlana A. Chechetka, Eijiro Miyako, Kanyi Pu*.Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons.Journal of the American Chemical Society,2016,138, 9049.

10、Qingqing Miao,Yan Lyu (co-first author), Dan Ding, Kanyi Pu*.Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH.Advanced Materials,2016,28, 3662.

五、联系方式

通讯地址:无锡市蠡湖大道1800号威尼斯官网

邮编:214122

Email:yan_lyu@jiangnan.edu.cn